Immediately after winning your fortune, take a leave of absence form your place of employment, or simply quit. Remember though, quitting your job does not mean quitting your work. Labor has a special value which helps each one of us define our sense of self-worth.
Nailing down exactly what sort of work is most rewarding for you is a process of self-discovery, a process that your winnings can assist at speeding up. So go ahead and chill out for a while by taking a vacation. Bask in doing and saying nothing for a couple of weeks, months, whatever you need, while you plan your future. Sure, your life may never be the same again, but this does not necessarily mean you will never work again.